Rocilinostat ( ACY-1215 )

Catalog No. M11280 CAS No. 1316214-52-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Rocilinostat
Note

Research use only, not for human use.
Brief Description

Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay.
Description

Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Phase 2.
Synonyms

ACY-1215
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Research Area

Cancer
Indication

——

CAS Number

1316214-52-4
Formula Weight

433.50
Molecular Formula

C24H27N5O3
Purity

>98%(HPLC)
Solubility

DMSO: 86 mg/mL (198.38 mM)
SMILES

O=C(C1=CN=C(N(C2=CC=CC=C2)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O
Chemical Name

2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

1.Santo L, et al. Blood, 2012, 119(11), 2579-2589.

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